gae*_*cia 2 text-processing replace sed bioinformatics
我有一个以制表符分隔的遗传变异文件,其中有一INFO列包含许多分号分隔的标签:
Chr Start End Ref Alt ExAC_ALL ExAC_AFR ExAC_AMR ExAC_EAS ExAC_FIN ExAC_NFE ExAC_OTH ExAC_SAS Otherinfo QUAL DP Chr Start Ref Alt QUAL FILTER INFO
1 15847952 15847952 G C . . . . . . . . . 241.9 76196 1 15847952 . G C 241.9 PASS AC=2;AF=0;AN=18332;BaseQRankSum=0.731;ClippingRankSum=-0.731;DP=76196;ExcessHet=3.1;FS=0;InbreedingCoeff=-0.0456;MLEAC=2;MLEAF=0;MQ=38.93;MQRankSum=0.515;NEGATIVE_TRAIN_SITE;QD=10.52;ReadPosRankSum=0.89;SOR=0.481;VQSLOD=-1.406 culprit=MQ
1 15847963 15847963 A C . . . . . . . . . 1607.1 126156 1 15847963 . A C 1607.1 PASS AC=2;AF=0;AN=22004;BaseQRankSum=0.851;ClippingRankSum=-0.419;DP=126156;ExcessHet=3.4904;FS=0;InbreedingCoeff=0.0299;MLEAC=2;MLEAF=0;MQ=59.29;MQRankSum=0.18;QD=1.55;ReadPosRankSum=0.067;SOR=0.651;VQSLOD=0.995 culprit=QD
1 15847964 15847966 GCC - . . . . . . . . . 1607.1 126156 1 15847963 . AGCC A 1607.1 PASS AC=63;AF=0.003;AN=22004;BaseQRankSum=0.851;ClippingRankSum=-0.419;DP=126156;ExcessHet=3.4904;FS=0;InbreedingCoeff=0.0299;MLEAC=55;MLEAF=0.002;MQ=59.29;MQRankSum=0.18;QD=1.55;ReadPosRankSum=0.067;SOR=0.651;VQSLOD=0.995 culprit=QD
1 15847978 15847978 C T . . . . . . . . . 648.41 234344 1 15847978 . C T 648.41 PASS AC=9;AF=0;AN=25894;BaseQRankSum=-0.572;ClippingRankSum=-0.404;DP=234344;ExcessHet=3.348;FS=2.639;InbreedingCoeff=-0.0098;MLEAC=6;MLEAF=0;MQ=58.71;MQRankSum=-0.456;NEGATIVE_TRAIN_SITE;QD=4.13;ReadPosRankSum=-0.456;SOR=0.452;VQSLOD=-1.238 culprit=QD
Run Code Online (Sandbox Code Playgroud)
我想拆分 INFO 列中的前 3 个以分号分隔的术语:
AC=2;AF=0;AN=18332
Run Code Online (Sandbox Code Playgroud)
使他们成为:
AC=2 AF=0 AN=18332 BaseQRankSum=0.731;ClippingRankSum=-0.731;DP=76196;ExcessHet=3.1;FS=0;InbreedingCoeff=-0.0456;MLEAC=2;MLEAF=0;MQ=38.93;MQRankSum=0.515;NEGATIVE_TRAIN_SITE;QD=10.52;ReadPosRankSum=0.89;SOR=0.481;VQSLOD=-1.406 culprit=M
Run Code Online (Sandbox Code Playgroud)
到目前为止,我已经尝试了以下表达式sed:
sed -i .bk 's/\(A.=.*\);/\1 /g' allChr_ExAC38.hg38_multianno.txt
Run Code Online (Sandbox Code Playgroud)
但这不会产生任何变化。
理想情况下,我正在寻找一种方法来告诉sed将分号的前 3 次出现替换;为 a tab,但's/;/ /g3'似乎并不是那个意思。
使用 Perl 代替 sed:
perl -i.bk -pe '$c = 0; s/;/\t/ while $c++ < 3' -- file.txt
Run Code Online (Sandbox Code Playgroud)